The acute therapy

combi pack
(KadeFungin®3 Kombi-Packung)

Contains 3 vaginal tablets (200 mg clotrimazole each) with applicator and 20g cream (2% clotrimazole).
  • For pruritus, burning and redness in the genital area
  • The effective 3-day therapy
  • Suitable during pregnancy and lactation

* No. 1 according to packs sold, IH Galaxy ApoFusion 08/2021

Vaginal yeast infection
is no longer
an issue
for me!

Application / duration

  • One vaginal tablet in the evening on 3 consecutive days
  • Vaginal cream 3 times a day for 3 consecutive days
  • No treatment during menstruation. Treatment should be completed before menstruation begins
  • Once opened, do not use the cream for longer than 6 months

Application / duration

  • One vaginal tablet in the evening on 3 consecutive days
  • Vaginal cream 3 times a day for 3 consecutive days
  • No treatment during menstruation. Treatment should be completed before menstruation begins
  • Once opened, do not use the cream for longer than 6 months

Preparation of the applicator

  • Pull out the applicator rod as far as it will go
  • Insert the vaginal tablet into the applicator

Placement of the vaginal tablet

  • Assume a supine position with the legs slightly bent and insert the applicator with the vaginal tablet as deep as possible into the vagina
  • Press the applicator rod as far as it will go
  • Pull the applicator out of the vagina

Cleaning the applicator

  • Pull the rod completely out of the applicator
  • Clean with warm water and let dry
  • Assemble the applicator after drying

5 tips

for protecting yourself against vaginal yeast infection:

Clean your intimate area gently with a special intimate wash lotion or with water only to avoid disturbing the natural milieu.

Change washcloths and underwear daily and wash them at least at 60°C.

Avoid using non-breathable trousers and underwear made of synthetic materials that cannot be washed at high temperatures.

If your partner is suspected of being infected, he should seek medical advice and, if necessary, also undergo treatment.

Do not use intimate deodorants or vaginal douches – these too disrupt the natural balance.

KadeFungin 3 combi pack

Precautions for use

Do not use:

  • in combination with deodorants or products for intimate hygiene, as they may reduce effectiveness
  • in combination with latex condoms, as tear strength may be reduced
  • in case of hypersensitivity to any of the ingredients

Use during pregnancy only after consulting a doctor and without applicator.


Vaginal tablet containing 200 mg clotrimazole Adipic acid, lactose monohydrate, magnesium stearate (Ph. Eur.), pre-agglutinated corn starch, sodium hydrogen carbonate, polysorbate 80, highly dispersed silicon dioxide, stearic acid

Cream containing 2% clotrimazole (20mg clotrimazole in 1g of cream) Benzyl alcohol, cetyl palmitate (Ph. Eur.), cetylstearyl alcohol (Ph. Eur.), octyldodecanol (Ph. Eur.), polysorbate 60, sorbitan stearate, purified water


No special storage conditions

Why does the pack include an applicator?

An applicator serves as an insertion aid for vaginal tablets, vaginal gels and vaginal creams. It helps introducing the active ingredient deep enough into the vagina. If the vaginal tablet, vaginal gel or vaginal cream are not introduced sufficiently deep, the substance-containing component may leak out from the vagina, which reduces the efficacy. This may compromise the therapy of the vaginal yeast infection. Rigid applicators should not be used during pregnancy due to the risk of injury. However, some applicators have been designed for use during pregnancy. The package insert must be consulted in this regard.

Can KadeFungin 3 be used during menstruation?

Treatment of a vaginal yeast infection using KadeFungin 3 is not effective during a menstrual period, as the active ingredient clotrimazole is flushed out of the vagina with the menstrual blood. Accordingly, it should not be used during menstruation. Should the menstrual period occur during the 3-day treatment with KadeFungin 3, treatment should be interrupted and performed again for 3 consecutive days after the period. Likewise, the vaginal yeast will not proliferate greatly during the menstrual period. During this phase of the menstrual cycle, the level of oestrogen is low. Glycogen, which the Candida yeast requires as a nutrient to proliferate, is formed by the cells of the vaginal lining, and is dependent on oestrogen. Due to the limited supply of nutrients, the yeast cannot spread further in the genital area, resulting in less pronounced symptoms of the vaginal yeast infection.

Can children/young girls be treated with KadeFungin 3?

No general age limit is specified in the instructions for use of KadeFungin 3. However, a yeast infection is only possible if sufficient oestrogen is available. Oestrogen stimulates the cells of the vaginal lining to produce glycogen, a long-chain sugar. Yeasts causing vaginal infections require glycogen as a nutrient in order to multiply. It is only during puberty or sexual maturation that the ovaries receive the signal to produce oestrogen. Shortly before the first menstruation, sufficient oestrogen is available in the vaginal region to develop vaginal yeast infections. Most girls have their first menstrual period between the age of 12 and 13 years, although its onset may be slightly earlier or later.

In contrast, girls in childhood are in the hormonal resting phase and do not produce any oestrogen. A yeast infection is therefore unlikely. However, a vaginal infection may also occur in early childhood. A vaginal infection at this age is mostly of bacterial origin. The genital inflammation is mostly limited to the external genitalia. A paediatrician should be consulted if a genital infection is suspected in a child.

Is the use advisable in postmenopausal/older women?

The ovaries gradually cease hormone production during menopause. Hence, levels of oestrogen are reduced after this stage of life. Because of this, the availability of glycogen as a nutrient is also insufficient for vaginal yeast to proliferate. Glycogen is produced in the vaginal cells under the influence of oestrogen. Vaginal yeast infections are therefore rather unlikely in postmenopausal women who are not receiving hormone therapy. Yeast infections that may occur in postmenopausal women are usually limited to the genital labia. In contrast to vaginal yeast in women of childbearing potential, this most often concerns an infection with Candida glabrata rather than Candida albicans. Candida glabrata is relatively insensitive to clotrimazole, the active ingredient in KadeFungin3. Treatment with other antifungal agents, such as nystatin or ciclopiroxolamine, is required in such cases.

However, postmenopausal women can also suffer from symptoms such as itching and burning in the genital area. The cause is often an atrophy of the layers of the vaginal wall caused by low oestrogen levels, which is associated with vaginal dryness. Here, a treatment of the oestrogen deficiency with local oestrogens is recommended. In cases where oestrogens cannot be prescribed due to a contraindication, a hyaluronic acid-containing moisturising gel or Ovula (vaginal suppository) may be used to alleviate symptoms.

How serious is the accidental oral intake of a vaginal tablet?

Although the accidental ingestion of the vaginal tablet may in some cases cause nausea and abdominal pain, no serious side effects are known. After oral ingestion, the active ingredient clotrimazole is broken down by the liver into inactive products which are excreted. Accordingly, treatment of the yeast infection does not take place. A consistent and proper 3-day therapy is necessary for a successful treatment of vaginal yeast with KadeFungin3. This means that 1 vaginal tablet should be inserted into the vagina in the evening for 3 consecutive days.

Since this is a case of improper use, albeit an unintentional one, we as the manufacturer ask you to contact us. As a pharmaceutical company, we are obliged to record the improper use of our preparations. Thank you for your cooperation.

Our contact details:
0800 999 52 3333 free of charge
[email protected]

What if the vaginal tablet hasn't completely dissolved?

If the vagina is sufficiently moistened, the vaginal tablet can dissolve completely. The active ingredient spreads evenly over the vaginal lining and can penetrate the tissue. In some cases, a minor vaginal reflux of the tablet residues may take place. This does not affect the efficacy.

In case of vaginal dryness, i.e. when the vagina is not sufficiently moistened, the use of the KadeFungin3 vaginal tablet is not useful. In such cases, a vaginal yeast infection should be treated with KadeFungin3 vaginal cream. At body temperature, the cream liquefies in the vagina and spreads evenly over the vaginal lining. This results a successful treatment of a vaginal yeast infection. Please note that the treatment of vaginal yeast infections will not be successful if the vaginal tablet has not dissolved sufficiently.

If the vaginal tablet does not dissolve sufficiently, larger loose pieces of the vaginal tablet will exit the vagina. In individual cases, in presence of vaginal dryness, the entire vaginal tablet may be discharged again from the vagina. In this specific situation, we as the manufacturer ask you to contact us. As a pharmaceutical company, we are obliged to record the improper use of our preparations. Thank you for your cooperation.

Our contact details:
0800 999 52 3333 free of charge
[email protected]

Is the contraceptive effectiveness of contraceptive rings impaired?

Studies by the manufacturer of a contraceptive ring (NuvaRing) do not provide any indication of potential interactions between the hormonal active ingredients and an antimycotic vaginal cream (miconazole). Accordingly, one can assume absence of interactions with clotrimazole, the active ingredient in KadeFungin3. However, residues of the dissolved vaginal tablet or the base of the vaginal cream in the vagina can affect absorption of the active hormonal substances through the vaginal lining. This may impair the contraceptive effect of the contraceptive ring. Since no specific studies have been performed on the combination of KadeFungin3 with contraceptive rings, we kindly ask you to consult the manufacturer of the contraceptive ring. At the same time, it may be sensible to use additional contraception. In this context, please also note that KadeFungin3 affects condom safety.

Please consult your doctor or pharmacist for further information on KadeFungin® 3 combi pack.

KadeFungin® 3 combi pack, vaginal tablets and cream. (KadeFungin® Kombi-Packung)
Active ingredient: clotrimazole.
Areas of application: Infections of the vagina and external genital area by yeasts (usually Candida albicans). The cream contains benzyl alcohol and cetostearyl alcohol. Please see package leaflet. For risks and side effects, read the package leaflet or ask your doctor or pharmacist. Last revised: 12/2023 DR. KADE Pharmazeutische Fabrik GmbH, Berlin

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